This came out around the time that the original DS - the big, clunky one - was hitting its stride. The games mentioned are Ridge Racer DS, Kirby Canvas Curse, Phoenix Wright: Ace Attorney, and Trauma Center: Under the Knife.
And yes, that was an actual DS slogan.
I know that the name of the mental hospital in the last panel was a joke of some kind, but for the life of me I can't remember what it was. I think it may have had something to do with the Hitchhiker's Guide to the Galaxy.